BBSRC Portfolio Analyser
Award details
An exploration of factors contributing to senescence of cerebrospinal fluid secretory mechanisms
Reference
S15339
Principal Investigator / Supervisor
Dr Jane Preston
Co-Investigators /
Co-Supervisors
Dr Malcolm Segal
,
Dr Michael Wilson
Institution
King's College London
Department
School of Health and Life Sciences
Funding type
Research
Value (£)
67,022
Status
Completed
Type
Research Grant
Start date
01/11/2001
End date
01/11/2002
Duration
12 months
Abstract
The cerebrospinal fluid (CSF) plays a key role in maintaining brain nutrient homeostasis, delivering hormones and drugs to target sites and removing toxins/waste products. CSF is actively secreted by choroid plexuses (CP) which also synthesize CSF proteins, including thyroxine- and growth factor-binding proteins, essential for normal brain function. With increasing age CSF protein levels alter and fluid turnover declines, and may contribute to brain ageing. This project aims to identify key factors in CP ageing e.g. altered ion transport (driving force for CSF secretion), energy availability (ATP production, glucose consumption), protein synthetic capacity and integrity of the blood-CSF barrier, of relevance to brain and CSF ageing.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search