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How does Wolbachia kill male insects?
Reference
S15317
Principal Investigator / Supervisor
Professor Gregory Hurst
Co-Investigators /
Co-Supervisors
Dr Henk Braig
Institution
University College London
Department
Genetics Evolution and Environment
Funding type
Research
Value (£)
174,112
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2005
Duration
36 months
Abstract
Wolbachia is an intracellular bacterium found in over 20 percent of insect species. In many species, it shows sex specific virulence, killing male hosts only, death occurring during embryogenesis. This study will investigate how males are killed. We will examine the anatomy of male death in a natural host, Drosophila bifasciata, and assess the timing of and cellular pathology of death, and the role of bacterial proliferation. We will transfect D. melanogaster with the bacterium, and determine the cue used by the bacterium to detect host maleness by examining male-killing efficiency in hosts mutant for a variety of genes involved with sex determination.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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