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Building a central synapse in Drosophila: a synaptogenesis between the GF and TTMn
Reference
S15289
Principal Investigator / Supervisor
Dr Jane Davies
Co-Investigators /
Co-Supervisors
Professor Jonathan Bacon
Institution
University of Sussex
Department
Biology and Environmental Science
Funding type
Research
Value (£)
317,124
Status
Completed
Type
Research Grant
Start date
03/09/2001
End date
03/09/2004
Duration
36 months
Abstract
The synapse between the giant fibre (GF) and tergotrochanteral muscle motorneuron (TTMn) is the most accessible synapse in the CNS of Drosophila and uniquely is amenable to both genetic and physiological approaches. Using a combination of molecular biology, genetics, electrophysiology and electron microscopy, we propose to examine the structure, functional properties and development of this synapse. The ease of genetic manipulation in the fly, combined with the ability to test directly any effect on synaptic function by electrophysiology, makes this a very powerful system for unravelling the mechanisms involved in the formation of a central synapse.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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