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Natural antisense RNA regulation of nNOS expression in an identified neuron

ReferenceS15286
Principal Investigator / Supervisor Professor Michael O'Shea
Co-Investigators /
Co-Supervisors
Professor Paul Benjamin, Professor Julian Burke, Dr Sergei Korneev
Institution University of Sussex
DepartmentBiology and Environmental Science
Funding typeResearch
Value (£) 296,300
StatusCompleted
TypeResearch Grant
Start date 01/12/2001
End date 31/08/2005
Duration45 months

Abstract

There are few eukaryotic models for assessing molecular mechanisms and functional consequences of natural antisense RNA. Recently however we have found that a NOS-related gene produces antisense RNA which acts as a negative regulator of nNOS protein synthesis in a giant identified neuron in the snail (Lymnaea). We will exploit this discovery using molecular genetic techniques applied to single identified neurones to address the following questions: 1) What genes are involved in regulating the expression of the antisense RNA? 2) In the context of the known behavioural role of nNOS, what is the function of antisense regulation of nNOS expression?

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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