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Natural antisense RNA regulation of nNOS expression in an identified neuron

Reference	S15286
Principal Investigator / Supervisor	Professor Michael O'Shea
Co-Investigators / Co-Supervisors	Professor Paul Benjamin, Professor Julian Burke, Dr Sergei Korneev
Institution	University of Sussex
Department	Biology and Environmental Science
Funding type	Research
Value (£)	296,300
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	31/08/2005
Duration	45 months

Abstract

There are few eukaryotic models for assessing molecular mechanisms and functional consequences of natural antisense RNA. Recently however we have found that a NOS-related gene produces antisense RNA which acts as a negative regulator of nNOS protein synthesis in a giant identified neuron in the snail (Lymnaea). We will exploit this discovery using molecular genetic techniques applied to single identified neurones to address the following questions: 1) What genes are involved in regulating the expression of the antisense RNA? 2) In the context of the known behavioural role of nNOS, what is the function of antisense regulation of nNOS expression?

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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