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Natural antisense RNA regulation of nNOS expression in an identified neuron
Reference
S15286
Principal Investigator / Supervisor
Professor Michael O'Shea
Co-Investigators /
Co-Supervisors
Professor Paul Benjamin
,
Professor Julian Burke
,
Dr Sergei Korneev
Institution
University of Sussex
Department
Biology and Environmental Science
Funding type
Research
Value (£)
296,300
Status
Completed
Type
Research Grant
Start date
01/12/2001
End date
31/08/2005
Duration
45 months
Abstract
There are few eukaryotic models for assessing molecular mechanisms and functional consequences of natural antisense RNA. Recently however we have found that a NOS-related gene produces antisense RNA which acts as a negative regulator of nNOS protein synthesis in a giant identified neuron in the snail (Lymnaea). We will exploit this discovery using molecular genetic techniques applied to single identified neurones to address the following questions: 1) What genes are involved in regulating the expression of the antisense RNA? 2) In the context of the known behavioural role of nNOS, what is the function of antisense regulation of nNOS expression?
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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