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Characterising the role of APC phenotype and activation state in the induction of Th1/Th2 responses in vivo
Reference
S15196
Principal Investigator / Supervisor
Professor James MacDonald Brewer
Co-Investigators /
Co-Supervisors
Professor Paul Garside
Institution
University of Glasgow
Department
Immunology & Bacteriology
Funding type
Research
Value (£)
170,840
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/03/2005
Duration
41 months
Abstract
Low frequencies of antigen-specific precursor lymphocytes in normal mice has precluded analysis of the role of antigen presenting cell (APC) population involved during Th1/Th2 cell differentiation in vivo. However, by transferring antigen receptor transgenic T cells into naive mice, we can track this expanded population in vivo. This project will investigate which APC phenotypes are involved in antigen presentation during the induction of Th1 or Th2 responses by in vivo immunisation protocols and characterise the activation states and location of these cells. These studies will improve our understanding of T cell-interactions underlying the induction of immunity in vivo.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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