Award details

Phenotypic characterisation of phosphoinositide 3-kinase gene-targeted mice

Reference	S15153
Principal Investigator / Supervisor	Professor Bart Vanhaesebroeck
Co-Investigators / Co-Supervisors	Professor Eric Lam
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	298,404
Status	Completed
Type	Research Grant
Start date	04/06/2001
End date	04/06/2004
Duration	36 months

Abstract

This proposal seeks to define the physiological roles of the p110 alpha and p110 delta phosphoinositide 3- kinases (PI3Ks) by gene targeting in mice. These enzymes are important conveyors of intracellular signals downstream of tyrosine kinases and Ras. Studies in cell lines have implicated p110 alpha in the regulation of cell growth, proliferation and survival, while p110 delta has been shown to be important in the regulation of the actin cytoskeleton and cell migration. It remains to be established whether these enzymes play a similar role in the organism. We are creating mice in which the genes for these P13Ks have been inactivated in a constitutive or in a conditional manner, and are now looking to phenotypically characterise these animals with a focus on the immunological and cell biological investigation of leukocyte functions.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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