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Fish and chips: Indentifying and quantifying xenobiotic-induced alterations of gene expression in the brain and gonad
Reference
S15001
Principal Investigator / Supervisor
Professor Charles Tyler
Co-Investigators /
Co-Supervisors
Professor Peter Kille
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
266,580
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
03/02/2005
Duration
40 months
Abstract
We have produced some of the strongest evidence worldwide for endocrine disruption in wildlife and played a central role in developing testing systems for endocrine disrupting chemicals (EDCs) in fish. Almost nothing is known, however, of the effects of environmental chemicals on gene expression. We propose to establish some of the first fish DNA arrays to assess the effects of EDCs on the expression of genes controlling reproduction in fish and quantify these responses with established cellular and tissue reproductive end points. The approach we will adopt will also help us to establish mechanisms of action of EDCs and identify other, unspecified, genes in the brain and gonad whose expression is altered by exposure to EDCs.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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