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Glutamate and GABA receptors associated with primary afferent terminals in laminae I-III of the rat spinal cord

Reference	S14994
Principal Investigator / Supervisor	Professor Andrew Todd
Co-Investigators / Co-Supervisors	Professor David J. Maxwell
Institution	University of Glasgow
Department	Neuroscience & Biomedical Systems Divisi
Funding type	Research
Value (£)	231,132
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	30/11/2004
Duration	40 months

Abstract

Fine primary afferents, many of which function as nociceptors, end in the superficial dorsal horn of the spinal cord where they synapse on various types of neuron, including projection cells that convey nociceptive information to the brain. These afferents release glutamate and this acts on NMDA and AMPA receptors, both of which are important in pain mechanisms. Primary afferent transmission is under presynaptic control, involving both GABAA and GABAB receptors. We will use a sensitive post- embedding immunocytochemical method to examine the distribution of NMDA and AMPA receptors at synapses between nociceptive afferents and identified projection neurons, and also determine the types of GABA receptor present on each class of fine afferent.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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