Award details

The long-term neuroendocrine regulation of energy balance in a seasonal mammal: a genetic and experimental approach

Reference	S14761
Principal Investigator / Supervisor	Professor Andrew Loudon
Co-Investigators / Co-Supervisors	Dr Felino Cagampang, Dr Andrew Hayes
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	316,588
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	01/01/2004
Duration	36 months

Abstract

This proposal aims to define key molecular events underpinning seasonal metabolism using the Siberian hamster model in which annual cycles of appetite, metabolic rate and fat deposition are driven by the photoperiod/melatonin axis. Seasonal changes in hypothalamic and CNS gene expression will be defined using characterised cDNA arrays derived from hypothalamic libraries and a hamster-specific library developed from a suppressive subtractive hybridisation screen. We aim to discover known and novel genes involved in the long-term management of energy metabolism. Arrayed libraries will be screened with cDNAs from several physiological model systems and common patterns of photoperiod-modulated gene expression defined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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