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Functional topographical and molecular characterisation of stress-responsive versus non-responsive serotonergic systems
Reference
S14666
Principal Investigator / Supervisor
Professor Stafford Lightman
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Henry Wellcome Labs for Neuroscience & E
Funding type
Research
Value (£)
327,196
Status
Completed
Type
Research Grant
Start date
01/03/2001
End date
31/08/2004
Duration
42 months
Abstract
Although it is widely accepted that serotonergic neuronal systems play a role in modulating behavioural, autonomic, and neuroendocrine responses to stress, the topographical distribution of stress-responsive serotonergic neurones in the brainstem is poorly understood. Recent work in our laboratory has identified a topographically organised subpopulation of serotonergic neurones, associated with a distributed mesolimbocortical neural system involved in behavioural anxiety, that is responsive to the anxiogenic neuropeptide, corticotrophin-releasing factor (CRF), and is responsive to certain forms of stress-related stimuli. The proposed studies are designed to characterise the functional, topographical, and molecular properties of this novel subpopulation of serotonergic neurones.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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