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Are all trkA and IB4+ve sensory neurones nociceptive? Studies of their membrane properties and relative contributions to chronic pain states
Reference
S14627
Principal Investigator / Supervisor
Professor Sally Lawson
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Physiology and Pharmacology
Funding type
Research
Value (£)
158,448
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
30/09/2004
Duration
38 months
Abstract
We plan to examine the widely held but not directly tested assumption that two neuronal markers can identify two largely non-overlapping groups of specifically nociceptive neurones. These markers are trkA, the high affinity NGF receptor, and the lectin IB4. IB4+ neurones express receptors for GDNF. Immunocytochemistry of individual neurones whose sensory properties have been identified in vivo, will establish whether these markers are specific for nociceptors in normal and chronic pain states. Changes in membrane properties in nociceptive neurones may underlie hyperalgesia in chronic pain states. We shall study how such changes differ between trkA+ and IB4+ cells during inflammation or following peripheral nerve injury; and how sequestering or adding NGF or GDNF affects the membrane properties in these two groups of cells.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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