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The CNS regulation of the reproductive axis in male rats by prolactin-releasing peptide (PrRP)
Reference
S14616
Principal Investigator / Supervisor
Professor Mohammad Ghatei
Co-Investigators /
Co-Supervisors
Professor Stephen Bloom
,
Dr Caroline Small
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
169,400
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
Prolactin-releasing peptide (PrRP) was recently isolated from the hypothalamus. We have shown it to activate the hypothalamo-pituitary-gonadal (HPG) axis, causing a 3-fold rise in plasma testosterone, comparable to LHRH, the most powerful stimulus known. To understand the physiology of PrRP's potent effect on testosterone, we will study: 1) co-localization of PrRP and its receptors with hypothalamic peptides known to influence the HPG axis, 2) the dose-response and in vivo mapping of the hypothalamic nuclei mediating PrRP's activation of the HPG axis, 3) changes in PrRP mRNA, peptide, and receptor mRNA with altered sex hormone and nutritional environment, 4) effects of PrRP on the fasting induced inhibition of the HPG axis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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