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An integrated genomic and proteomic analysis of the development and sexual differentiation of schistosome parasites
Reference
S14608
Principal Investigator / Supervisor
Professor Alan Wilson
Co-Investigators /
Co-Supervisors
Dr Peter Ashton
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
201,356
Status
Completed
Type
Research Grant
Start date
01/04/2001
End date
01/04/2004
Duration
36 months
Abstract
The parasitic flatworm Schistosoma undergoes a complex larval development and displays both sexual differentiation and pairing-induced reproductive maturation. Understanding these processes has important implications for vaccine development and control of pathology. Schistosome genomics are now sufficiently advanced to permit meaningful functional analysis of the underlying mechanisms. We propose an integrated macroarray and proteomics approach to map changes in transcription and translation profiles associated with (i) transformation from infective cercaria to migrating schistosomulum and (ii) development, sexual differentiation and reproductive maturation, triggered by arrival in the hepatic portal system. This will identify stage- and sex-specific changes in expression, and provide an initial characterisation of differentially expressed genes.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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