Award details

An integrative genomic approach to the mechanisms underlying mammalian hibernation

Reference	S14607
Principal Investigator / Supervisor	Professor Andrew Cossins
Co-Investigators / Co-Supervisors	Dr Andrew Gracey
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	171,688
Status	Completed
Type	Research Grant
Start date	15/09/2001
End date	15/09/2003
Duration	24 months

Abstract

Hibernation is certainly the most dramatic modification of a systems-level homeostasis in mammals. Yet despite widespread interest in the phenomenon and its value as a model for analysis of hypometabolism, hypothermic survival and thermoregulatory adaptations, our understanding of the underlying mechanisms is fragmentary and incomplete. We propose to take advantage of the power of the cDNA microarray technique to identify those genes whose transcript expression changes during preparation for or as a result of entry into hibernation. This project will identify novel response systems throughout almost the entire body, and will provide an integrated view of tissue-specific and global gene level responses that is appropriate to the post- genomic era. It will also provide a suite of resources for the functional evaluation of specific genes and their products in hibernation and following experimental manipulation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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