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Analysing Apc function in mammary epithelium
Reference
S14598
Principal Investigator / Supervisor
Professor Alan Clarke
Co-Investigators /
Co-Supervisors
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
325,300
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
16/07/2004
Duration
37 months
Abstract
The adenomatous polyposis coli (Apc) protein has been attributed multiple roles impacting upon cytoskeletal integrity, cellular adhesion and Wnt signalling. Inactivation of Apc is known to predispose to malignancy, but the fundamental biological role of Apc in normal epithelium remains unclear. Constitutive loss of Apc leads to embryonic lethality, precluding any loss of function studies. We have used Cre-Lox technology to inactivate Apc in the mammary gland. Preliminary results show Apc to be critical to normal development and lactation. However, these studies leave many unresolved questions concerning the basic biology of Apc within the mammary epithelium. This proposal will exploit conditional Apc loss to resolve these questions.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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