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Are bone marrow NMDA receptor positive cells the elusive CFU-Fs?
Reference
S14571
Principal Investigator / Supervisor
Professor T M Skerry
Co-Investigators /
Co-Supervisors
Dr Katherine Dobson
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
198,680
Status
Completed
Type
Research Grant
Start date
01/03/2002
End date
30/09/2004
Duration
31 months
Abstract
Pilot studies show that early inhibition of glutamate signalling in marrow cultures causes dramatic reduction in bone formation. We hypothesise that the few glutamate receptor +ve mononuclear cells in marrow are pluripotent CFU-F progenitor cells, or that they influence CFU-Fs. To test the hypothesis, we will determine the effect of GluR antagonists in vivo on numbers of GluR+ve cells and colony formation in vitro. We will sort GluR +ve cells, and characterise their expression of osteoblastic, chondrogenic and adipocytic markers. We will investigate the ability of conditioned media from these cells to influence the differentiation of GluR- ve marrow cells in the presence or absence of neutralising antibodies to candidate paracrine factors.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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