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The role of AMPA and kainate receptors in expression of behaviours conditioned to drug reward
Reference
S14554
Principal Investigator / Supervisor
Professor David Stephens
Co-Investigators /
Co-Supervisors
Dr Andy Mead
Institution
University of Sussex
Department
Biology and Environmental Science
Funding type
Research
Value (£)
251,188
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
The importance of AMPA and kainate receptors in plastic changes induced by psychostimulant drugs in neuronal systems signalling reward will be studied: a) By modifying the subunits making up glutamatergic receptors (the GluR1, GluR2 (AMPA receptor), or GluR6 (kainate receptor) subunits) we will study the importance of these receptor subtypes in models of drug reward; b) Neuronal activity induced by amphetamine and cocaine, and stimuli conditioned to them, will be assessed in brain regions implicated in reward following receptor modification ; c) Changes in subunit expression will be assessed in the same brain areas by immunochemistry and in situ hybridisation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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