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Reactive oxygen species the inner zone antigen and steroid hormone secretion

Reference	S14524
Principal Investigator / Supervisor	Professor Gavin P Vinson
Co-Investigators / Co-Supervisors	Dr Stewart Barker
Institution	Queen Mary University of London
Department	Sch of Biological and Chemical Sciences
Funding type	Research
Value (£)	218,836
Status	Completed
Type	Research Grant
Start date	04/01/2001
End date	04/01/2004
Duration	36 months

Abstract

We have shown that Mn-superoxide dismutase (Mn-SOD) is a hormone-inducible component specifically expressed in the inner zones (fasciculata/reticularis) of the adrenal cortex, but not in the glomerulosa. The findings suggest that redox state and/or reactive oxygen species (ROS) signalling may be involved in the regulation of specific endocrine functions and steroid hormone production. Using the antibodies, cDNAs and other tools at our disposal, we will study the regulation of ROS generation in relation to hormone output in the rat adrenal cortex, and its relationship to Mn-SOD expression and function. We will also address the possibility that inner zone antigen that we have now identified as a member of a novel membrane located steroid binding protein family, with the same cellular distribution as Mn-SOD, may be functionally linked to Mn-SOD and ROS signalling.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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