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125 dihydroxyvitamin D3 HOXA10 and fetal implantation: a novel role for extra-renal expression of 1alpha hydroxylase
Reference
S14523
Principal Investigator / Supervisor
Professor Martin Hewison
Co-Investigators /
Co-Supervisors
Dr Judith Bulmer
,
Professor Mark Kilby
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
210,248
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
The immunological nature of fetal implantation is illustrated by the repertoire of haematopoietic cell sub-sets within the decidua. Furthermore, both trophoblastic and decidual cells express the enzyme lalpha- hydroxylase (1-HYD) which catalyzes synthesis of active vitamin D 1,25-dihydroxyvitamin D3 (1,25D3), a potent immunosuppressive steroid hormone. The proposed project will address the hypothesis that production of 1,25D3 by macrophage-like cells in human decidua plays an important role in implantation by regulating expression of the homeobox, HOXA10 gene in an autocrine/paracrine fashion. Human tissue analysis, flow cytometry and in vitro models will be used to determine the relationship between HOXA10 and 1,25D3 in implantation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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