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Pyrogenicity and apoptosis-inducing activity of recombinant influenza viruses produced by reverse genetics
Reference
S14126
Principal Investigator / Supervisor
Dr Clive Sweet
Co-Investigators /
Co-Supervisors
Professor H Smith
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
190,252
Status
Completed
Type
Research Grant
Start date
01/03/2001
End date
01/03/2004
Duration
36 months
Abstract
Infection with influenza virus results in respiratory and constitutional symptoms; the former probably follows release of kinins and cytokines by respiratory epithelial cells undergoing apoptosis while constitutional symptoms (e.g. fever) result from endogenous pyrogen (probably pro-inflammatory cytokine) release from phagocytes. Virion components are involved in the induction of both fever and apoptosis. The current proposal is to identify such components and their active sites using a new reverse genetics protocol. This allows production, entirely from cDNA, of defined recombinant and mutant infectious influenza virus, containing genes from viruses which are good inducers (clone 7a) or poor inducers (A/Fiji) of fever and apoptosis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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