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Control of chicken class 1 peptide-binding specificities by polymorphic chicken TAPs
Reference
S14072
Principal Investigator / Supervisor
Professor Jim Kaufman
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
158,940
Status
Completed
Type
Research Grant
Start date
21/06/2001
End date
21/06/2004
Duration
36 months
Abstract
Transporters for antigen presentation (TAPs), which pump antigenic peptides into the endoplasmic reticulum, are polymorphic in chickens, and preliminary data suggest that TAPs have the crucial role in determining the repertoire of peptides presented by class I molecules to the chicken immune system. This work will examine the role in three ways: 1) by comparing peptide specificities from in vitro assays for peptide-translocation by TAPs and peptide-binding by class I molecules; 2) by examining specificities of interaction in vivo by co- transfection of chicken class I with various TAPs; and 3) by investigating the potential role of TAPs as targets for viral immune evasion. The results will be of both fundamental and strategic importance.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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