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The role of metabotropic glutamate receptors in synaptic plasticity in perirhinal cortex

Reference	S13975
Principal Investigator / Supervisor	Professor Zafar Bashir
Co-Investigators / Co-Supervisors	Professor Malcolm Brown, Professor Kwangwook Cho
Institution	University of Bristol
Department	Anatomy
Funding type	Research
Value (£)	224,071
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	01/04/2004
Duration	43 months

Abstract

The perirhinal cortex is involved in several different forms of learning and memory, including visual recognition memory. We shall investigate the roles of mGlu receptors in synaptic plasticity (especially LTD) in perirhinal cortex in vitro and the mobilisation of intracellular calcium in cultures of perirhinal cortex neurones. We shall then determine, using newly available pharmacological tools and glutamate receptor knockouts, whether those mechanisms that are important in synaptic plasticity are also important in the neural mechanisms of visual recognition memory in perirhinal cortex. Thus we shall test the hypothesis that long-term synaptic plasticity and visual recognition memory share common underlying mechanisms.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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