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Generation of MHC class 1 tetramers for measuring CTL responses to RSV in infected and immunised cattle
Reference
S13972
Principal Investigator / Supervisor
Professor Shirley Ellis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
211,320
Status
Completed
Type
Research Grant
Start date
02/01/2001
End date
02/01/2004
Duration
36 months
Abstract
The recently developed MHC class I tetramer technology will be adapted and optimised for use with cattle MHC class I genes. A number of characterised genes and peptides will be assessed during the first stage of the project. The resulting reagents will be used to quantitatively and qualitatively analyse T cell responses in cattle to respiratory syncytial virus, an important pathogen of young animals. This technique is unique in that it allows direct isolation of MHC and peptide-specific T cells from peripheral blood and tissues. It will be possible to study the kinetics, longevity and functional characteristics of antigen specific T cells following infection with RSV. In addition it will allow evaluation of vaccines under development.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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