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Comparative expression profiling in the three defined forms of ovine paratuberculosis
Reference
S13964
Principal Investigator / Supervisor
Professor John Hopkins
Co-Investigators /
Co-Supervisors
Dr M Sinclair
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
204,080
Status
Completed
Type
Research Grant
Start date
04/01/2001
End date
04/04/2004
Duration
39 months
Abstract
The aims of the project are to: 1) to identify the intrinsic differences in the way that macrophages from asymptomatic, paucibacillary and multibacillary forms of paratuberculosis respond to Map infection; and 2) to compare immuno- inflammatory gene expression in gut-associated lymphoid tissue and relate those differences to the different pathological forms of paratuberculosis. These aims will be achieved by analysing immuno-inflammatory gene expression of infected macrophages and GALT using functional genomics (microarray) technology. Consequently, a major task will be to construct, verify and validate an oligonucleotide microarray of ruminant immuno-inflammatory genes.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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