Award details

Cell matrix interactions in follicle growth and oocyte production

Reference	S13899
Principal Investigator / Supervisor	Professor Martin Luck
Co-Investigators / Co-Supervisors	Professor Morag Hunter, Professor Helen Picton, Professor Robert Webb
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	215,336
Status	Completed
Type	Research Grant
Start date	01/05/2001
End date	19/09/2004
Duration	41 months

Abstract

This study aims to understand the mechanism of bovine ovarian follicular growth at the cellular and biochemical levels and, using this knowledge, to develop improved systems for the production of oocytes in vitro. The study will focus on the interaction of granulosa and theca cells in remodelling the wall of the growing follicle, and the control of these processes by gonadotrophins, IGFs and FGFs. Key methods will include granulosa-theca co-culture, follicle culture, zymography, electron microscopy and in situ hybridisation. By determining the factors limiting intact follicle wall development in culture, we will devise more successful culture protocols for the production of developmentally component oocytes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search