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Function and expression of hyperglycaemic hormone from gut endocrine cells of crabs: new models of moult control

Reference	S13837
Principal Investigator / Supervisor	Professor Simon Webster
Co-Investigators / Co-Supervisors	Dr Jum Chung
Institution	Bangor University
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	226,756
Status	Completed
Type	Research Grant
Start date	20/09/2000
End date	20/09/2003
Duration	36 months

Abstract

This project aims to study the roles of neuropeptides during ecdysis in crabs, particularly hyperglycaemic hormone (CHH) from gut endocrine cells (paraneurones), which is synthesised during premoult, and released just prior to moulting. This peptide controls water uptake during ecdysis. The objectives are: 1) to identify the hormonally mediated ion transport mechanisms involved in this process; 2) to determine gut CHH gene expression patterns (and possible regulation by ecdysteroids during premoult), and seasonal alternative splicing of transcripts; and 3) to investigate interendocrine mechanisms involved in novel hormone cascades, including CHH, crustacean cardioactive peptide (CCAP), and new roles for other neuropeptides in ecdysis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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