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Analysis of the proteome of tachyzoites and bradyzoites of toxoplasma gondii

Reference	S13819
Principal Investigator / Supervisor	Professor Jonathan Wastling
Co-Investigators / Co-Supervisors	Professor Graham Herbert Coombs
Institution	University of Glasgow
Department	Infection & Immunity
Funding type	Research
Value (£)	205,076
Status	Completed
Type	Research Grant
Start date	01/02/2001
End date	01/02/2004
Duration	36 months

Abstract

Toxoplasma gondii is a coccidian parasite that is a widespread cause of animal disease and has important implications for public health. The development of novel vaccines or new drug therapies requires a better knowledge of the fundamental molecular and biochemical processes that mediate successful parasitism. T. gondii occurs in two asexual developmental forms: the rapidly multiplying tachyzoites and the slowly dividing bradyzoites. We will exploit modern proteomic technologies including two-dimensional electrophoresis, quantitative computer analysis and mass spectrometry to identify key protein differences between tachyzoites and bradyzoites. This will provide a deeper understanding of the biochemical and metabolic adaptations of bradyzoites to their environment. and help identify putative new drug targets.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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