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Targeting mutant connexin 26 genes to mouse epidermis: the role of gap junctions in epidermal structure and physiology

Reference	S13811
Principal Investigator / Supervisor	Dr Malcolm Briden Hodgins
Co-Investigators / Co-Supervisors	Dr Rukhsana Choudhry, Professor Malcolm Finbow, Dr David Greenhalgh
Institution	University of Glasgow
Department	Dermatology
Funding type	Research
Value (£)	305,508
Status	Completed
Type	Research Grant
Start date	01/03/2001
End date	31/12/2004
Duration	46 months

Abstract

The mammalian epidermis forms a physical barrier essential to survival. It has been proposed that coupling of epidermal keratinocytes by gap junctions between and within epidermal layers is an essential mechanism in regulating normal epidermal architecture and barrier function. We will test this hypothesis by targeting recently discovered dominant mutants of connexin 26 (a gap junction protein specifically induced in stressed epidermis) to the epidermis of mice by conventional transgenic technologies, and by studying the effects upon epidermal structure and patterns of gap junctional intercellular communication. The work will provide novel methods for further detailed analysis of the role of connexins in the epidermis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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