Award details

Acetylcholinesterases in parasitic nematodes: mediators of persistence and targets for chemotherapy

Reference	S13808
Principal Investigator / Supervisor	Professor Murray Selkirk
Co-Investigators / Co-Supervisors	Professor Jacqueline Matthews
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	178,628
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	01/10/2003
Duration	36 months

Abstract

We will investigate secreted acetylcholinesterases (AChEs) in the parasitic nematodes Dictyocaulus viviparus and Nippostrongylus brasiliensis, with a view to determining their role in manipulation of host physiological responses and parasite persistence. The cellular specificity and dynamics of acetylcholine receptor expression in lungs and draining bronchial lymph node of D. viviparus- infected animals and the localisation of parasite secreted AChEs in pulmonary and intestinal tissues will be determined. We will also determine the primary structure and properties of neuronal AChEs from both species, and examine both neuronal and secreted enzymes as targets for selective inhibitors. (Joint with grant 26/S13809.)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S13809 Acetylcholinesterases in parasitic nematodes: mediators of persistence and targets for chemotherapy

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