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Signal transduction pathways and neuronal mechanisms underlying the central effects of PRL on the control of fertility
Reference
S13552
Principal Investigator / Supervisor
Dr Domingo Jorge Tortonese
Co-Investigators /
Co-Supervisors
Dr Michael Norman
Institution
University of Bristol
Department
Anatomy
Funding type
Research
Value (£)
142,548
Status
Completed
Type
Research Grant
Start date
15/01/2001
End date
15/01/2004
Duration
36 months
Abstract
The neural mechanisms underlying the suppressive effects of prolactin (PRL) on reproduction remain unclear. Although PRL receptors (R) were detected in the hypothalamus and PRL was shown to inhibit GnRH release, the identity of the neurones expressing PRL-R, the PRL-R isoform mediating central PRL effects and the signal transduction pathways involved are unknown. This project will investigate the neural mechanisms by which PRL regulates fertility, specifically: 1) whether the long or short from PRL-R is differentially expressed in the brain; 2) the neurochemical identity of neurones expressing PRL-R; 3) the signal transduction pathways activated by PRL; and 4) the physiological role of central PRL-R in the control of gonadotrophin secretion.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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