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Structure and function of a lectin implicated in the interaction of malaria parasite with the mosquito midgut
Reference
S13517
Principal Investigator / Supervisor
Dr Peter Billingsley
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Inst of Biological and Environmental Sci
Funding type
Research
Value (£)
217,296
Status
Completed
Type
Research Grant
Start date
17/10/2000
End date
17/10/2003
Duration
36 months
Abstract
This project will characterise molecular components involved in mosquito susceptibility to malarial infection. A novel mannan-binding haemolymph lectin from adult females of the mosquito, An. stephensi, binds complex carbohydrates on RBCs, bacteria, fungi, and malarial ookinetes. The lectin will be further characterised in three ways: 1) biochemical and physical: to include native molecular weight, subunit organisation, pI, monoclonal antibody production, N- terminal sequence and peptide mapping; 2) functional: identification of the ookinete surface ligand(s), the role of the lectin in malarial infection; and 3) molecular: full length cDNA sequence and expression dynamics following feeding and parasite infection.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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