Award details

Angiotensin II and male fertility

Reference	S13504
Principal Investigator / Supervisor	Professor Lynn Fraser
Co-Investigators / Co-Supervisors	Professor Gavin P Vinson
Institution	King's College London
Department	GKT School of Biomedical Sciences
Funding type	Research
Value (£)	182,892
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	31/03/2004
Duration	39 months

Abstract

Mammalian sperm have angiotensin II (AII) receptors, seminal plasma contains AII and AII stimulates sperm motility/capacitation/fertilisation in vitro. These data suggest an important role for AII in male fertility in vivo, but raise key questions about AIIs source and availability in relation to sperm function. We will study, in normal and transgenic male rodents: 1) formation of AII in the reproductive tract (particularly tissue sources of seminal plasma AII) and its hormonal regulation; 2) correlation of AII availability with key events in sperm function (e.g. capacitation, acrosome reaction); and 3) mechanisms of action following AII binding to sperm. Findings will have implications for new approaches to fertility regulation. (Joint with grant 68/S13512)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S13512 Angiotensin II and male fertility

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