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CNS gene expression in a mouse model of scrapie

Reference	S13418
Principal Investigator / Supervisor	Professor John Fazakerley
Co-Investigators / Co-Supervisors	Professor Alun Williams
Institution	University of Edinburgh
Department	Veterinary Pathology
Funding type	Research
Value (£)	195,172
Status	Completed
Type	Research Grant
Start date	30/10/2000
End date	31/12/2002
Duration	26 months

Abstract

This is a proposal for an explorative investigation of the molecular neuropathogenesis of the transmissible spongiform encephalopathies. The aim is to undertake a comprehensive genomics based screen of CNS gene transcription in both a mouse model (ME7 infection of C57BL VM/Dk [Sinc s7p7] mice) and a tissue culture system of scrapie. The study will build on our present project investigating transcription of cytokine genes in the brains of infected mice. A major strength will be the linking of the molecular data generated to the extensive histopathological and clinical data uniquely available in this in vivo model system and to the neuronal death events observed in the in vitro system. The results will enable a more directed and rational approach to future hypothesis led research to determine the mechanism of neuropathology of these important diseases.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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