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Role of purinergic P2X7 receptors in the regulation of brain interleukin-1

Reference	S13358
Principal Investigator / Supervisor	Professor Nancy Rothwell
Co-Investigators / Co-Supervisors	Dr Rosalind LeFeuvre
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	202,216
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

Interleukin-1 beta is a primary mediator of neuroimmune interactions and neurodegeneration, but little is known about what regulates its expression or release. The proposed study will test the hypothesis that purinergic P2x7 receptors regulate the activation and release of IL-1beta in the brain. This will be achieved by in vivo studies of neuronal death induced by cerebral ischaemia, which is mediated by IL-1. Studies will investigate actions of P2X7 agonists and antagonists on neuronal death, IL-1 and IL-18 cleavage and release, localised IL-1 and P2X7 receptors, and will compare responses in normal animals and mice in which the P2x7, IL-1, caspase 1 or IL-18 genes have been deleted.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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