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Response of insect host gene expression to infection by DNA viruses
Reference
S13231
Principal Investigator / Supervisor
Dr Julie Olszewski
Co-Investigators /
Co-Supervisors
Dr David O'Reilly
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
104,111
Status
Completed
Type
Research Grant
Start date
16/10/2000
End date
16/10/2002
Duration
24 months
Abstract
Insect host cell responses to infection by two insect viruses that are from unrelated taxa, the baculoviruses and entomopoxviruses, will be studied with regard to effects on host cell transition. The temporal expression of HaEPV infection in Df9 cells will be established as well as effects on host protein synthesis by timecourse labelling experiments. AcMNPVrotein and HaEPVrotein infected Sf9 cells will be monitored for steady state RNA levels of several proteins of known function by Northern blot analysis. Infected cell time-course samples will be compared to uninfected cells, using modified differential display technology to identify differentially expressed transcripts, which will be isolated and sequenced.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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