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Peripheral targets of circadian clocks
Reference
S13205
Principal Investigator / Supervisor
Professor Julian Dow
Co-Investigators /
Co-Supervisors
Professor Shireen Davies
Institution
University of Glasgow
Department
Molecular Genetics
Funding type
Research
Value (£)
244,280
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
31/10/2003
Duration
36 months
Abstract
Circadian rhythms enable organisms to tune their interactions with the environment, and the nature of the clock mechanism is now being unravelled. We plan to address the targets of the clock, in the context of the Drosophila Malpighian (renal) tubule, that is known to possess an intrinsic, independent clock. This project will: 1) characterise the physiological properties of the tubule, throughout the light/dark cycle; 2) monitor circadian transcriptome-wide changes using microarrays; and 3) extend our analyses to the available mutants of period, timeless, clock, cycle and cryptochrome. In combination, these results will give a unique insight into the downstream targets of the circadian clock in Drosophila, and by inference, in other animals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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