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Functional analysis of Haemonchus and Teladorsagia GATA factors using C. elegans as a heterologous expression system

Reference	S13196
Principal Investigator / Supervisor	Professor John Gilleard
Co-Investigators / Co-Supervisors	Professor Andrew Tait
Institution	University of Glasgow
Department	Veterinary Infection and Immunity
Funding type	Research
Value (£)	248,872
Status	Completed
Type	Research Grant
Start date	10/07/2000
End date	10/07/2003
Duration	36 months

Abstract

Haemonchus contortus and Teladorsagia circumcincta are gastrointestinal parasites of great economic and welfare importance to the sheep industry. Like most parasitic nematodes they are difficult experimental subjects. In contrast, the nematode Caenorhabditis elegans is one of the most tractable and intensively studied organisms in biology. We propose to develop C. elegans as a tool to study parasite gene function. We will focus on the GATA transcription factors; key regulators of hypodermal and gut development in C. elegans. We will clone orthologous parasite genes, examine their expression patterns and use C. elegans as a heterologous expression system to study gene function and identify differences from their vertebrate counterparts.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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