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Expression cloning of axonal growth factors from a blastema cDNA library

Reference	S13012
Principal Investigator / Supervisor	Dr john pizzey
Co-Investigators / Co-Supervisors	Professor Roger Patient, Dr David Alan Tonge
Institution	King's College London
Department	Reproductive Health Endocrinology Dev
Funding type	Research
Value (£)	196,036
Status	Completed
Type	Research Grant
Start date	01/07/2000
End date	22/08/2003
Duration	38 months

Abstract

During embryonic development, sensory and motor axons grow to innervate specific limb regions, but the mechanisms by which axons are induced to grow into limbs and are guided to their correct destinations have yet to be defined. Regenerating limbs in urodeles have been widely used as a model system for limb development and show normal patterns of innervation. In recent experiments, we have found that blastemas formed during early stages of limb regeneration can attract growth of primary sensory axons in vitro. The main objective of this project is to use an expression cloning strategy to isolate potentially novel axonal growth factors which are expressed in regeneration blastemas of urodele limbs. The cellular mechanisms by which axons navigate to their appropriate destinations within developing and regenerating limbs will also be investigated.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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