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Body weight and reproductive cycles in a seasonal mammal and the action of leptin
Reference
S12833
Principal Investigator / Supervisor
Professor Andrew Loudon
Co-Investigators /
Co-Supervisors
Dr Felino Cagampang
,
Professor David Lovejoy
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
199,441
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
01/05/2003
Duration
36 months
Abstract
This study investigates links between leptin and reproduction in the seasonally breeding Siberian hamster where photoperiod drives major changes in metabolism, body fat reserves and reproduction. Physiological levels of leptin will be administered and changes in hypothalamic drive on the reproductive system monitored by measuring LH output in steroid- clamped animals. We will thus establish whether leptin is capable of reactivating reproduction in photoperiodically suppressed adult animals as well as in animals in which LH secretion is suppressed by under-nutrition. The hypothalamic expression of orexogenic/anorexic peptides, including the CRF/urocortin axis will be determined and the linkage to leptin/photoperiod defined.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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