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Interactions between electrical activity and gap junctions in regulation of cell proliferation and death in the retina
Reference
S12815
Principal Investigator / Supervisor
Professor David Becker
Co-Investigators /
Co-Supervisors
Professor Peter Mobbs
Institution
University College London
Department
Cell and Developmental Biology
Funding type
Research
Value (£)
203,040
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
05/05/2003
Duration
40 months
Abstract
Control of cell numbers in the central nervous system is reached through a balance between cell proliferation and programmed cell death. These processes are likely to be influenced by calcium waves generated by spontaneous electrical activity which spread among cells during development of the nervous system, and the extensive network of gap junctions between these cells. Using a retinal model, we will modulate gap junctional expression or conductance and spontaneous calcium waves with pharmacological or molecular tools and investigate their role in cell proliferation and programmed cell death.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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