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A study of the spinal mechanisms regulating the pathophysiology of inflammatory hyperalgesia in sheep

Reference	S12792
Principal Investigator / Supervisor	Professor Andrea Nolan
Co-Investigators / Co-Supervisors	Dr Sharron Dolan
Institution	University of Glasgow
Department	Department of Veterinary Pre-clinical St
Funding type	Research
Value (£)	261,972
Status	Completed
Type	Research Grant
Start date	08/03/2000
End date	08/03/2003
Duration	36 months

Abstract

Hyperalgesia, a state of increased responsiveness to noxious stimuli, is of major welfare importance in animals, and its presence may be regarded as an indicator of an abnormal pain state. In sheep, activation of spinal glutamate receptor and prostaglandin pathways are known to play important roles in spinal nociceptive processing. This project aims to test the hypotheses that a) hyperalgesia associated with acute and chronic inflammation is modulated by differential alterations in PG pathways, b) mGluRs play a selective and specific role in nociception and inflammatory hyperalgesia in sheep and interact with iGluRs via cAMP-PKA pathway and c) that rapid alterations in transcription factors modify gene expression in spinal cord tissue which mediate acute hyperalgesia, which may be susceptible to manipulation with non-steroidal anti-inflammatory drugs.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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