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Shaping of developing retinal receptive fields by retinal waves
Reference
S12779
Principal Investigator / Supervisor
Professor Evelyne Sernagor
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
Clinical and Laboratory Sciences
Funding type
Research
Value (£)
171,192
Status
Completed
Type
Research Grant
Start date
01/08/2000
End date
31/07/2003
Duration
36 months
Abstract
In the developing vertebrate retina, synchronised spontaneous bursting activity in neighbouring ganglion cells results in propagating waves. Using calcium imaging and electrophysiological techniques, this project will investigate whether the spatiotemporal patterns encoded in the waves are instructive for the development of retinal connectivity. Activity patterns of the waves and their underlying synaptic circuitry will be investigated in the developing retina. Activity patterns will be modified chemically in ovo (without abolishing the waves) and, the effects of these chronic alterations on the development and the refinement of retinal receptive fields will be assessed. These experiments are essential for understanding whether spontaneous activity plays an instructive or permissive role in the development of neural connections.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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