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Host and parasite interactions in Xenopus species
Reference
S12169
Principal Investigator / Supervisor
Professor Richard Tinsley
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biological Sciences
Funding type
Research
Value (£)
226,301
Status
Completed
Type
Research Grant
Start date
22/11/1999
End date
22/11/2002
Duration
36 months
Abstract
This study is based on a naturally-occurring system; infections of Xenopus species by the monogenean helminth parasite Protopolystoma. The remarkable evolutionary biology of Xenopus, involving hybridisation and genome duplication, has generated a polyploid series (with 2n=20/40, 36, 72, 108). This creates an exceptional system for studies of host-parasite interactions, including parasite specificity, host susceptibility/resistance, and the regulation of infection by the immune response. A series of dovetailed approaches will document interactions in field samples (including museum collections) and recreate these in a programme of experimental infections enabling interpretation of immune mechanisms and co-evolutionary relationships.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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