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The regulation of opsin gene expression in retinal rods
Reference
S12149
Principal Investigator / Supervisor
Professor David Hunt
Co-Investigators /
Co-Supervisors
Professor Julian Partridge
Institution
University College London
Department
Institute of Ophthalmology
Funding type
Research
Value (£)
212,080
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
28/11/2003
Duration
49 months
Abstract
Switches in the expression of genes encoding G-protein linked cell membrane receptors are known during ontogeny in several species of vertebrate, including mammals. In the European eel, a switch occurs in the expression of two genes encoding different forms of rod opsin, resulting in the sequential production of different forms of rod visual pigment with differing peak sensitivities. The two genes have been cloned and sequenced. The project will investigate the control of this gene switch by following the binding of nuclear proteins to the 5' flanking regions of the two genes during the switch-over period, and will identify the transcription factors involved in this process.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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