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Type I interferon mediated defence in a natural gammaherpesvirus infection

Reference	S12143
Principal Investigator / Supervisor	Professor Anthony Nash
Co-Investigators / Co-Supervisors	Professor James Stewart
Institution	University of Edinburgh
Department	Veterinary Pathology
Funding type	Research
Value (£)	342,730
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	01/01/2003
Duration	36 months

Abstract

Type I Interferon (IFN) is a major arm of the innate immune response to virus infection. Relatively little is known about the action of IFN against gammaherpesviruses, a group of viruses associated with widespread disease in man and livestock. Using murine gammaherpesvirus we plan to study virological and host factors in IFN-mediated resistance. This will include: a) use of radiation chimeras and gene KO mice to dissect the impact of IFN on virus and cellular gene expression in epithelial cells and leucocytes in infected tissues. b) the function of PKR, RNAseL, and NK cells in IFN-mediated resistance mechanisms. c) the role of IFN in B cell infection and the establishment of virus latency, and d) the significance of viral tRNA expression as a disruptor of the IFN-mediated intra- cellular defences.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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