Award details

The roles of CD40 and CD154 in haematopoiesis and immunological tolerance

Reference	S12061
Principal Investigator / Supervisor	Dr A Heath
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Genomic Medicine
Funding type	Research
Value (£)	55,211
Status	Completed
Type	Research Grant
Start date	07/08/2000
End date	07/02/2002
Duration	18 months

Abstract

CD450 may be expressed early in murine B cell ontogeny and be down-regulated at the immature stage. Self reactive immature B cells are eliminated in the marrow following antigen (Ag) receptor ligation, and CD40 ligation prevents this. B cells reactive with CD154 would be activated in the periphery, thus they must be deleted in the bone marrow by Ag receptor ligation by CD154. However in the presence of CD154 a CD40 expressing cell would be rescued. We propose CD40 is down-regulated at the immature stage to allow elimination of those potentially harmful B cells with Ag receptors which bind CD154 or possibly other T cell activation antigens. The proposed study will test this hypothesis. (Joint grant with 36/S12053)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S12053 The roles of CD40 and CD154 in haematopoiesis and immunological tolerance

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