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The mechanisms of T cell-induced mucosal growth in the gut

Reference	S11925
Principal Investigator / Supervisor	Professor Thomas MacDonald
Co-Investigators / Co-Supervisors	Professor Gad Frankel
Institution	University of Southampton
Department	Inflammation Infection and Repair
Funding type	Research
Value (£)	228,561
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	31/10/2003
Duration	46 months

Abstract

T cell immune reactions in the gut mucosa are associated with changes in mucosal shape. In the small bowel the stereotypic response is villus atrophy and crypt hyperplasia and in the colon it is mucosal thickening and crypt hyperplasia. Here we will use a new model of colitis elicited by the intimin of enteropathogenic E. coli transfected into the mouse pathogen Citrobacter rodentium, and colitic IL-2 knockout mice, to investigate the pathways by which activated T cells remodel colonic mucosa. We will focus on the production of epithelial growth factors, extracellular matrix production and degradation, and stromal cell proliferation during the evolution and resolution of intimin colitis. In addition we will use knockout mice (KGF, TGF alpha, MMP3 and TIMP-1) to determine which are the critical molecules in vivo.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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