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Genetic control of the development of CNS asymmetries and behavioural lateralisation in zebrafish

Reference	S11913
Principal Investigator / Supervisor	Professor Richard Andrew
Co-Investigators / Co-Supervisors	Professor Stephen Wilson
Institution	University of Sussex
Department	Biology and Environmental Science
Funding type	Research
Value (£)	164,757
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/10/2002
Duration	36 months

Abstract

Validated screening tests for zebrafish fry show reversal of one aspect of lateralisation in cardiac reversed fish (UCL stock) but not another (age-dependent shifts in bias). Mutants from UCL facility would be screened for further right/left disturbances, which would be explored by a battery of tests for adults, and new tests for fry (e.g. using eye movements). Location of CNS asymmetries would be probed by (available) markers for genes expressed symmetrically in the CNS, which would be applied to embryos of established lines. Possible secondary effects of early asymmetry (e.g. asymmetric photic input via the pineal) would be studied to clarify causation. Mutant lines with interesting phenotypes would be used to identify the gene(s) concerned (where possible by candidate gene procedures; this would allow extrapolation to vertebrates in general).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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