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Molecular mechanism of Wolbachia-induced cytoplasmic incompatability: identification of the maternal rescue factor
Reference
S11854
Principal Investigator / Supervisor
Dr Henk Braig
Co-Investigators /
Co-Supervisors
Institution
Bangor University
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
197,824
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
08/09/2003
Duration
40 months
Abstract
Wolbachia-driven cytoplasmic incompatibility (CI) is one of the most powerful and universal forces to spread new genes and phenotypes like refractoriness to disease transmission into natural insect populations. Yet the single most important vector of malaria, the Anopheles mosquito, might not be able to support Wolbachia. This proposal aims to unravel the molecular mechanism behind Wolbachia-induced CI and wishes to identify the molecules responsible. Then the corresponding genes can be transferred onto the chromosomes of vector insects that cannot support this bacterium. The working hypothesis is that Wolbachia imprints the phenotype onto the sperm which causes a disruption of the synchronisation of sperm and egg pronuclei de/recondensation. The phenotype is rescued by a maternal Wolbachia factor which acts in the egg cell; this proposal will identify the maternal rescue factor.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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