Award details

Physiological characterisation of novel (VA) retinal photoreceptors

Reference	S11820
Principal Investigator / Supervisor	Professor Mark Hankins
Co-Investigators / Co-Supervisors	Professor Russell Foster
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	151,636
Status	Completed
Type	Research Grant
Start date	01/03/2000
End date	01/03/2003
Duration	36 months

Abstract

The rod and cone photoreceptors have been thought to mediate all of the varied light responses of the retina. Our recent studies, however, show that a sub-set of horizontal cells in the fish retina contain a novel photopigment (VA opsin). The overall aims of this proposal are to study the physiological of these novel retinal photoreceptors and place VA photoreception into a functional context. Using the carp, this proposal combines the electrophysiological, molecular, and anatomical expertise of two laboratories (Hankins and Foster) to undertake the following projects: a) Study the electrophysiological responses of isolated VA photoreceptors; b) Confirm the horizontal cell class/classes that express VA- opsin; c) Characterise the transduction pathway of VA photoreceptors; d) Complete the functional express of carp VA opsin; e) Develop VA opsin antibodies for co- localisation studies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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